Supersymmetry was invented in the 1970s with the aim to find a symmetry that contains both gauge symmetry and space-time symmetry. To achieve this combination, supersymmetry assumes the existence of fermionic coordinates. This assumption is so bizarre, so unrelated to experiment, and so frequently repeated, that it has to be called a prejudice.
The issue that supersymmetry tried to address, the combination of gravity and gauge symmetry, remains important, of course. But the last 4 decades have clearly shown that supersymmetry is the wrong solution to the problem. Why is it wrong? It is wrong because coordinates are not fermionic; supersymmetry is the wrong solution to the problem. But supersymmetry is also wrong because it is born from the prejudice that fundamental physics need to search for higher symmetries; supersymmetry adresses a problem that is itself born from a prejudice.
Fundamental physics will not get out of its present impasse until people recognize that theories have to be built on data, not on prejudices.